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Edoxaban and Rifampin Oral, Intravenous

Determining the interaction of Edoxaban and Rifampin Oral, Intravenous and the possibility of their joint administration.

Check result:

Edoxaban <> Rifampin Oral, Intravenous

Relevance: 25.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using edoxaban together with rifAMPin is not recommended. Combining these medications may significantly decrease the blood levels and effects of edoxaban. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with rifampin may reduce the bioavailability of edoxaban. The proposed mechanism is rifampin induction of the P-glycoprotein efflux transporter, of which edoxaban is a substrate. According to the product labeling, rifampin decreased single-dose edoxaban systemic exposure (AUC) by approximately 35%.

MANAGEMENT: Concomitant use of edoxaban with rifampin should generally be avoided.

References

"Product Information. Savaysa (edoxaban)." Daiichi Sankyo, Inc., Parsippany, NJ.

Edoxaban

Generic Name: edoxaban

Brand name: Savaysa

Synonyms: n.a.

What is Edoxaban?

Rifampin Oral, Intravenous

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: Rifampin

What is Rifampin Oral, Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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