Edoxaban Tosylate and Phenytoin Capsules
Determining the interaction of Edoxaban Tosylate and Phenytoin Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Phenytoin may reduce the blood levels of edoxaban, which may make the medication less effective in preventing blood clots. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of P-glycoprotein (P-gp) may reduce the bioavailability of edoxaban, which is a substrate of the efflux transporter. According to the product labeling, the potent P-gp inducer rifampin decreased single-dose edoxaban systemic exposure (AUC) by approximately 35%.
MANAGEMENT: Caution is advised if edoxaban is used with P-gp inducers. Pharmacologic response to edoxaban should be monitored more closely whenever a P-gp inducer is added to or withdrawn from therapy, and the edoxaban dosage adjusted as necessary.
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- "Product Information. Savaysa (edoxaban)." Daiichi Sankyo, Inc., Parsippany, NJ.
Generic Name: edoxaban
Brand name: Savaysa
Synonyms: Edoxaban
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Edoxaban Tosylate-Phenytoin Chewable Tablets
- Edoxaban Tosylate-Phenytoin Extended-Release Capsules
- Edoxaban Tosylate-Phenytoin Infatabs
- Edoxaban Tosylate-Phenytoin injection
- Edoxaban Tosylate-Phenytoin Intravenous
- Edoxaban Tosylate-Phenytoin Oral Suspension
- Phenytoin Capsules-Edrophonium and Atropine
- Phenytoin Capsules-Edrophonium Injection
- Phenytoin Capsules-Edurant
- Phenytoin Capsules-EEMT
- Phenytoin Capsules-EEMT DS
- Phenytoin Capsules-EEMT HS