Edoxaban Tosylate and Rifampin
Determining the interaction of Edoxaban Tosylate and Rifampin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using edoxaban together with rifAMPin is not recommended. Combining these medications may significantly decrease the blood levels and effects of edoxaban. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with rifampin may reduce the bioavailability of edoxaban. The proposed mechanism is rifampin induction of the P-glycoprotein efflux transporter, of which edoxaban is a substrate. According to the product labeling, rifampin decreased single-dose edoxaban systemic exposure (AUC) by approximately 35%.
MANAGEMENT: Concomitant use of edoxaban with rifampin should generally be avoided.
- "Product Information. Savaysa (edoxaban)." Daiichi Sankyo, Inc., Parsippany, NJ.
Generic Name: edoxaban
Brand name: Savaysa
Synonyms: Edoxaban
Generic Name: rifampin
Brand name: Rifadin, Rifadin IV, Rimactane
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Edoxaban Tosylate-Rifampin and Isoniazid
- Edoxaban Tosylate-Rifampin Capsules
- Edoxaban Tosylate-Rifampin Injection
- Edoxaban Tosylate-Rifampin Intravenous
- Edoxaban Tosylate-Rifampin Oral, Intravenous
- Edoxaban Tosylate-Rifampin, Isoniazid, and Pyrazinamide
- Rifampin-Edrophonium and Atropine
- Rifampin-Edrophonium Injection
- Rifampin-Edurant
- Rifampin-EEMT
- Rifampin-EEMT DS
- Rifampin-EEMT HS