Edurant and Rifabutin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Rifabutin may significantly reduce the blood levels of rilpivirine, which may make it less effective in treating HIV infection. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the interaction, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with rifabutin may significantly decrease the plasma concentrations of rilpivirine. The proposed mechanism is rifabutin induction of the CYP450 3A4-mediated metabolism of rilpivirine. In 18 study subjects given rilpivirine 25 mg once daily with rifabutin 300 mg once daily, mean rilpivirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) were reduced by 31%, 42% and 48%, respectively. When rilpivirine was given at a higher dosage of 50 mg once daily with rifabutin, mean rilpivirine Cmax and AUC increased by 43% and 16% compared to rilpivirine administered alone at 25 mg once daily, while Cmin decreased by just 7%. The pharmacokinetics of rifabutin and its metabolite, 25-O-desacetylrifabutin, were not significantly altered by rilpivirine.

MANAGEMENT: When used concomitantly with rifabutin, the rilpivirine dosage should be increased from 25 mg once daily to 50 mg once daily, taken with a meal. Following the discontinuation of rifabutin, the rilpivirine dosage should be decreased to 25 mg once daily.

Edurant

Generic Name: rilpivirine

Brand name: Edurant

Synonyms: n.a.

What is Edurant?

Rifabutin

Generic Name: rifabutin

Brand name: Mycobutin

Synonyms: n.a.

What is Rifabutin?