Efavirenz and Orap

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using pimozide and efavirenz is not recommended. Taking these drugs together can affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with efavirenz may increase the plasma concentrations of pimozide. The proposed mechanism is competitive inhibition of pimozide metabolism via CYP450 3A4. Elevated plasma levels of pimozide have been associated with prolongation of the QT interval on the ECG; ventricular arrhythmias including ventricular tachycardia, ventricular fibrillation, and torsade de pointes; cardiac arrest; and sudden death.

MANAGEMENT: Given the potential for serious and life-threatening adverse cardiac events associated with increased plasma levels of pimozide, the concomitant use of efavirenz is considered contraindicated.

Efavirenz

Generic Name: efavirenz

Brand name: Sustiva

Synonyms: n.a.

What is Efavirenz?

Orap

Generic Name: pimozide

Brand name: Orap

Synonyms: n.a.

What is Orap?