Efavirenz Capsules and Zonisamide Capsules
Determining the interaction of Efavirenz Capsules and Zonisamide Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Efavirenz may reduce the blood levels and effects of zonisamide. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with drugs that are inducers of CYP450 3A4 may decrease the plasma concentrations and pharmacologic effects of zonisamide, which is primarily metabolized by the isoenzyme.
MANAGEMENT: Pharmacologic response to zonisamide should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the zonisamide dosage adjusted as necessary. Patients should be advised to notify their physician if they experience loss of seizure control.
- "Product Information. Zonegran (zonisamide)" Elan Pharmaceuticals, S. San Francisco, CA.
- Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83
Generic Name: efavirenz
Brand name: Sustiva
Synonyms: Efavirenz
Generic Name: zonisamide
Brand name: Zonegran
Synonyms: Zonisamide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Efavirenz Capsules-Zontivity
- Efavirenz Capsules-Zoo Friends
- Efavirenz Capsules-Zoo Friends Complete
- Efavirenz Capsules-Zoo Friends Gummies
- Efavirenz Capsules-Zorbtive
- Efavirenz Capsules-Zorcaine
- Zonisamide Capsules-Efavirenz Tablets
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- Zonisamide Capsules-Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate
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- Zonisamide Capsules-Efavirenz, Lamivudine, and Tenofovir Disoproxil Fumarate
- Zonisamide Capsules-Effaclor Duo