Efavirenz, emtricitabine, and tenofovir and Midazolam injection
Determining the interaction of Efavirenz, emtricitabine, and tenofovir and Midazolam injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using midazolam and efavirenz is not recommended. Taking these drugs together can cause symptoms of prlonged drowsiness, dizziness, confusion, or weak or shallow breathing. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Efavirenz may interfere with the metabolism of benzodiazepines. The mechanism is competitive inhibition of the CYP450 3A4 enzyme. The accumulation of benzodiazepines, especially midazolam and triazolam is associated with potentially serious and/or life-threatening events (e.g., prolonged sedation, respiratory depression).
MANAGEMENT: Midazolam or triazolam should not be administered concurrently with efavirenz.
- "Product Information. Sustiva (efavirenz)." DuPont Pharmaceuticals, Wilmington, DE.
Generic Name: efavirenz / emtricitabine / tenofovir
Brand name: Atripla
Synonyms: Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate
Generic Name: midazolam
Brand name: Versed, Nayzilam
Synonyms: Midazolam
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Efavirenz, emtricitabine, and tenofovir-Midazolam Injection Hospira
- Efavirenz, emtricitabine, and tenofovir-Midazolam nasal
- Efavirenz, emtricitabine, and tenofovir-Midazolam Nasal Spray
- Efavirenz, emtricitabine, and tenofovir-Midazolam Syrup
- Efavirenz, emtricitabine, and tenofovir-Midodrine
- Efavirenz, emtricitabine, and tenofovir-Midodrine Hydrochloride
- Midazolam injection-Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate
- Midazolam injection-Efavirenz, lamivudine, and tenofovir
- Midazolam injection-Efavirenz, Lamivudine, and Tenofovir Disoproxil Fumarate
- Midazolam injection-Effaclor Duo
- Midazolam injection-Effer-K
- Midazolam injection-Effer-K Tablets