Efavirenz, emtricitabine, and tenofovir and Warfarin
Determining the interaction of Efavirenz, emtricitabine, and tenofovir and Warfarin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using warfarin together with efavirenz may alter the effects of warfarin and cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Efavirenz may increase or decrease plasma concentrations and therapeutic effects of warfarin. The mechanism is alteration of CYP450 hepatic metabolism of warfarin R- and S-isomers. Other anticoagulants may be affected, as well.
MANAGEMENT: Until more information is available, INR monitoring is recommended and patients should be closely observed for clinical response. Patients should be advised to notify their physician if they experience any signs of excessive anticoagulation (e.g., unusual or prolonged bleeding, bruising, vomiting, change in stool or urine color, headache, dizziness, or weakness).
- "Product Information. Sustiva (efavirenz)." DuPont Pharmaceuticals, Wilmington, DE.
- Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90
Generic Name: efavirenz / emtricitabine / tenofovir
Brand name: Atripla
Synonyms: Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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