Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate and Imatinib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using imatinib together with efavirenz can alter the blood levels and effects of both medications. Specifically, imatinib levels may decrease, which may make the medication less effective. At the same time, efavirenz levels may increase. Contact your doctor if your condition changes or you experience increased side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Imatinib is a substrate as well as a potent competitive inhibitor of the CYP450 3A4 enzymatic pathway. Theoretically, pharmacokinetic interactions may occur during the coadministration of imatinib with drugs that act as both inducer and substrate of the metabolic pathway. However, data are currently insufficient to predict the potential consequences and clinical significance of such interactions.

MANAGEMENT: During concomitant therapy, the possibility of a diminished therapeutic response to imatinib should be considered. In addition, clinical and laboratory monitoring for potentially increased pharmacologic effects of concomitantly administered medications, particularly those with a narrow therapeutic range, may be appropriate.

Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate

Generic Name: efavirenz / emtricitabine / tenofovir

Brand name: Atripla

Synonyms: Efavirenz, emtricitabine, and tenofovir

What is Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate?

Imatinib

Generic Name: imatinib

Brand name: Gleevec

Synonyms: n.a.

What is Imatinib?