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Efavirenz Tablets and Ginkgo

Determining the interaction of Efavirenz Tablets and Ginkgo and the possibility of their joint administration.

Check result:

Efavirenz Tablets <> Ginkgo

Relevance: 16.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using ginkgo together with efavirenz. Ginkgo biloba has been reported to reduce the blood levels and effects of efavirenz, which may lead to progression of your HIV disease. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: An isolated case report suggests that coadministration with ginkgo biloba may decrease the plasma concentrations of efavirenz. The exact mechanism of interaction has not been established; however, the authors speculate that terpenoids in ginkgo biloba extract may induce efavirenz clearance via CYP450 3A4 metabolism and P-glycoprotein efflux. In the report, a 47-year-old HIV-positive patient who had received antiretroviral therapy for 10 years experienced virological failure months after he started using a ginkgo biloba extract. At the time of treatment failure, the patient had been receiving efavirenz for two years in combination with emtricitabine and tenofovir disoproxil fumarate. A mutation in the reverse transcriptase gene was demonstrated, and plasma samples dating back two years showed that efavirenz levels had decreased more than 50% over a period of 14 months, coinciding with increases in viral load. No other medication was initiated or discontinued during this timeframe, and patient was thought to be compliant.

MANAGEMENT: Until more data are available, patients treated with efavirenz should preferably avoid taking ginkgo biloba. In general, patients on antiretroviral therapy should consult a healthcare provider before taking any herbal or alternative medicine.

References

Wiegman DJ, Brinkman K, Franssen EJ "Interaction of Ginkgo biloba with efavirenz." AIDS 23 (2009): 1184-5

Efavirenz Tablets

Generic Name: efavirenz

Brand name: Sustiva

Synonyms: Efavirenz

What is Efavirenz Tablets?

Ginkgo

Generic Name: ginkgo

Brand name: Ginkgo biloba, Gingko Biloba

Synonyms: n.a.

What is Ginkgo?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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