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Efavirenz Tablets and Mycobutin

Determining the interaction of Efavirenz Tablets and Mycobutin and the possibility of their joint administration.

Check result:

Efavirenz Tablets <> Mycobutin

Relevance: 16.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using efavirenz together with rifabutin may decrease the effects of rifabutin. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Coadministration with efavirenz may decrease the plasma concentrations of rifabutin. The mechanism is efavirenz induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of rifabutin. In nine study subjects, efavirenz (600 mg once a day for 14 days) decreased the mean steady-state peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of rifabutin (300 mg once a day for 14 days) by 32% and 38%, respectively, compared to administration of rifabutin alone. Rifabutin had no significant effect on the pharmacokinetics of efavirenz.

MANAGEMENT: Efavirenz labeling and most experts recommend increasing the rifabutin dosage to 450 mg or 600 mg daily, or 600 mg two or three times per week, during coadministration with efavirenz.

References

Burman WJ, Jones BE "Treatment of HIV-related tuberculosis in the era of effective antiretroviral therapy." Am J Respir Crit Care Med 164 (2001): 7-12
"Notice to readers: updated guidelines for the use of rifabutin or rifampin for the treatment and prevention of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibiotrs." MMWR Morb Mortal Wkly Rep 49 (2000): 185-9
"Product Information. Sustiva (efavirenz)." DuPont Pharmaceuticals, Wilmington, DE.

Efavirenz Tablets

Generic Name: efavirenz

Brand name: Sustiva

Synonyms: Efavirenz

What is Efavirenz Tablets?

Mycobutin

Generic Name: rifabutin

Brand name: Mycobutin

Synonyms: n.a.

What is Mycobutin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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