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Efavirenz Tablets and Upadacitinib

Determining the interaction of Efavirenz Tablets and Upadacitinib and the possibility of their joint administration.

Check result:
Efavirenz Tablets <> Upadacitinib
Relevance: 16.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.MONITOR: Coadministration with moderate inducers of CYP450 3A4 may decrease the plasma concentrations of upadacitinib, which is primarily metabolized by the isoenzyme. The interaction may result in loss of or reduced clinical response. In study subjects, administration with the potent CYP450 3A4 inducer rifampin decreased upadacitinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 51% and 61%, respectively. MANAGEMENT: Caution is recommended if upadacitinib is used with moderate CYP450 3A4 inducers. Pharmacologic effects of upadacitinib should be monitored more closely whenever a moderate CYP450 3A4 inducer is added to or withdrawn from therapy. References "Product Information. Rinvoq (upadacitinib)." AbbVie US LLC, North Chicago, IL.

Professional:

MONITOR: Coadministration with moderate inducers of CYP450 3A4 may decrease the plasma concentrations of upadacitinib, which is primarily metabolized by the isoenzyme. The interaction may result in loss of or reduced clinical response. In study subjects, administration with the potent CYP450 3A4 inducer rifampin decreased upadacitinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 51% and 61%, respectively.

MANAGEMENT: Caution is recommended if upadacitinib is used with moderate CYP450 3A4 inducers. Pharmacologic effects of upadacitinib should be monitored more closely whenever a moderate CYP450 3A4 inducer is added to or withdrawn from therapy.

References
  • "Product Information. Rinvoq (upadacitinib)." AbbVie US LLC, North Chicago, IL.
Efavirenz Tablets

Generic Name: efavirenz

Brand name: Sustiva

Synonyms: Efavirenz

Upadacitinib

Generic Name: upadacitinib

Brand name: Rinvoq

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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