Elagolix and Gengraf Capsules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using elagolix together with cycloSPORINE is not recommended. Combining these medications may significantly increase the blood levels of elagolix. This can increase the risk and/or severity of side effects such as bone loss, depression, mood changes, suicidal thoughts, and liver problems. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with potent inhibitors of organic anion transporting polypeptide (OATP) 1B1 may significantly increase the plasma concentrations of elagolix, which is a substrate of the hepatic uptake transporter. In 12 study subjects, coadministration of single doses of 150 mg elagolix and 600 mg rifampin, a known OATP 1B1 inhibitor, increased elagolix peak plasma concentration (Cmax) and systemic exposure (AUC) by 337% and 458%, respectively, compared to elagolix administered alone. Increased exposure to elagolix may increase the risk of serious adverse effects such as bone loss, suicidal ideation and behavior, exacerbation of mood disorders, and hepatic transaminase elevations.

MANAGEMENT: Concomitant use of elagolix with potent OATP 1B1 inhibitors is considered contraindicated.

Elagolix

Generic Name: elagolix

Brand name: Orilissa

Synonyms: n.a.

What is Elagolix?

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?