Elagolix Sodium and Voriconazole Oral, Intravenous
Determining the interaction of Elagolix Sodium and Voriconazole Oral, Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Voriconazole may significantly increase the blood levels of elagolix. This can increase the risk and/or severity of side effects such as bone loss, depression, mood changes, suicidal thoughts, and liver problems. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. If both medications are necessary, it is generally recommended that the duration of concurrent use be limited to either 1 month or up to 6 months, depending on the dosage of elagolix you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of elagolix, which is a substrate of the isoenzyme. In 11 study subjects, administration of a single 150 mg dose of elagolix with 400 mg once daily dosing of ketoconazole, a potent CYP450 3A4 inhibitor, increased elagolix peak plasma concentration (Cmax) and systemic exposure (AUC) by 77% and 120%, respectively, compared to elagolix administered alone. Increased exposure to elagolix may increase the risk of serious adverse effects such as bone loss, suicidal ideation and behavior, exacerbation of mood disorders, and hepatic transaminase elevations.
MANAGEMENT: Concomitant use of elagolix 200 mg twice daily with potent CYP450 3A4 inhibitors for more than 1 month, or elagolix 150 mg once daily with potent CYP450 3A4 inhibitors for more than 6 months, is not recommended.
- "Product Information. Orilissa (elagolix)." AbbVie US LLC, North Chicago, IL.
Generic Name: elagolix
Brand name: Orilissa
Synonyms: Elagolix
Generic Name: voriconazole
Brand name: Vfend, Vfend
Synonyms: Voriconazole (oral/injection), Voriconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Elagolix Sodium-Voriconazole oral/injection
- Elagolix Sodium-Voriconazole Suspension
- Elagolix Sodium-Voriconazole Tablets
- Elagolix Sodium-Vorinostat
- Elagolix Sodium-Vortioxetine
- Elagolix Sodium-Vortioxetine Hydrobromide
- Voriconazole Oral, Intravenous-Elavil
- Voriconazole Oral, Intravenous-Elbasvir and grazoprevir
- Voriconazole Oral, Intravenous-Eldepryl
- Voriconazole Oral, Intravenous-Eldepryl Capsules
- Voriconazole Oral, Intravenous-Eldepryl Oral
- Voriconazole Oral, Intravenous-Eldepryl Tablets