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Elagolix Sodium and Zovia 1/50e

Determining the interaction of Elagolix Sodium and Zovia 1/50e and the possibility of their joint administration.

Check result:
Elagolix Sodium <> Zovia 1/50e
Relevance: 17.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ethinyl estradiol and other estrogen-containing medications may reduce the effectiveness of elagolix in treating your condition. If you require contraception, it is recommended that you use a non-hormonal form of contraception during treatment with elagolix and for one week after its discontinuation. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Since endometriosis is fueled by estrogen, coadministration with estrogen-containing medications including combination oral contraceptive pills is expected to reduce the efficacy of elagolix. The effect of progestin-only contraceptives is unknown. Elagolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist that inhibits endogenous GnRH signaling by binding competitively to GnRH receptors in the pituitary gland. Administration of elagolix results in dose-dependent suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to decreased levels of the ovarian sex hormones, estradiol and progesterone.

MANAGEMENT: Women requiring contraception should be advised to use non-hormonal forms of contraception during treatment with elagolix and for one week after its discontinuation.

References
  • "Product Information. Orilissa (elagolix)." AbbVie US LLC, North Chicago, IL.
Elagolix Sodium

Generic Name: elagolix

Brand name: Orilissa

Synonyms: Elagolix

Zovia 1/50e

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/50, Zovia 1/50E

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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