Elbasvir and grazoprevir and Nevirapine
Determining the interaction of Elbasvir and grazoprevir and Nevirapine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Elbasvir may reduce the blood levels of nevirapine, which may make the medication less effective in some cases. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of elbasvir and grazoprevir, both of which are substrates of the isoenzyme. In 10 study subjects, administration of elbasvir 50 mg once daily with efavirenz 600 mg once daily decreased elbasvir peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) by 45%, 54% and 59%, respectively, compared to administration of elbasvir alone. Likewise, when grazoprevir 200 mg once daily and efavirenz 600 mg once daily were given together to 12 study subjects, grazoprevir Cmax, AUC and Cmin decreased by 87%, 83% and 69%, respectively. Efavirenz is generally considered a moderate inducer of CYP450 3A4. The extent to which other, less potent inducers of CYP450 3A4 may interact with elbasvir and grazoprevir is unknown.
MANAGEMENT: The potential for diminished pharmacologic effects of elbasvir-grazoprevir should be considered during coadministration with CYP450 3A4 inducers. Alternative treatments may be required if an interaction is suspected.
- "Product Information. Zepatier (elbasvir-grazoprevir)." Merck & Company Inc, Whitehouse Station, NJ.
Generic Name: elbasvir / grazoprevir
Brand name: Zepatier
Synonyms: Elbasvir and Grazoprevir
Generic Name: nevirapine
Brand name: Viramune, Viramune XR
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Elbasvir and grazoprevir-Nevirapine Extended Release
- Elbasvir and grazoprevir-Nevirapine Extended-Release Tablets
- Elbasvir and grazoprevir-Nevirapine Oral Suspension
- Elbasvir and grazoprevir-Nevirapine Suspension
- Elbasvir and grazoprevir-Nevirapine Tablets
- Elbasvir and grazoprevir-New Day
- Nevirapine-Eldepryl
- Nevirapine-Eldepryl Capsules
- Nevirapine-Eldepryl Oral
- Nevirapine-Eldepryl Tablets
- Nevirapine-ELenzaPatch
- Nevirapine-Elepsia XR