Eldepryl and Tegsedi

• Generic Name: selegiline
• Dosage Forms: capsule
• Other Brand Names: Eldepryl, Zelapar, Emsam

Eldepryl (selegiline) prevents the breakdown of a chemical in your brain called dopamine. Low levels of dopamine are associated with Parkinson's disease.

Eldepryl capsules are used together with levodopa and carbidopa to treat symptoms of Parkinson's disease.

Eldepryl may also be used for purposes not listed in this medication guide.

• Generic Name: inotersen
• Dosage Forms: injection, solution
• Other Brand Names: Tegsedi

Tegsedi (inotersen) works by decreasing a protein called transthyretin (TTR, made primarily in the liver). Hereditary transthyretin-mediated amyloidosis (hATTR) is a rare condition in which abnormal deposits of TTR protein build up in many parts of the body, interfering with normal function.

Tegsedi injection is used to treat polyneuropathy (damage of multiple nerves throughout the body) in adults with hATTR. This medicine can help reduce symptoms such as pain, numbness, tingling, abnormal heartbeats, diarrhea, constipation, weakness, and problems with movement in your arms or legs.

Tegsedi is available only from a certified pharmacy under a special program.