Eliglustat and Lanoxin Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Eliglustat may increase the blood levels of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the interaction, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with eliglustat may increase the serum concentrations of digoxin. The proposed mechanism is eliglustat inhibition of the P-glycoprotein-mediated renal tubular secretion of digoxin. In CYP450 2D6 extensive and intermediate metabolizers given eliglustat 127 mg twice daily and poor metabolizers given 84 mg twice daily, mean digoxin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 1.7- and 1.5-fold, respectively, compared to digoxin administered alone.

MANAGEMENT: Serum digoxin levels should be measured prior to initiating eliglustat therapy. Eliglustat product labeling recommends reducing the digoxin dose by 30% with continued monitoring of serum levels. Patients should be advised to notify their physician if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

Eliglustat

Generic Name: eliglustat

Brand name: Cerdelga

Synonyms: n.a.

What is Eliglustat?

Lanoxin Tablets

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Lanoxin Tablets?