Eliglustat and Vitrakvi (Larotrectinib Capsules)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with eliglustat may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, liver, and/or kidney due to inhibition of P-glycoprotein-mediated drug efflux by eliglustat. When the P-gp probe substrate digoxin was given with eliglustat 127 mg twice daily in CYP450 2D6 extensive or intermediate metabolizers and 84 mg twice daily in poor metabolizers, mean digoxin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 1.7- and 1.5-fold, respectively, compared to digoxin administered alone. MANAGEMENT: Caution is advised when eliglustat is used concurrently with drugs that are known P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever eliglustat is added to or withdrawn from therapy. References "Product Information. Cerdelga (eliglustat)." Genzyme Corporation, Cambridge, MA.

MONITOR: Coadministration with eliglustat may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, liver, and/or kidney due to inhibition of P-glycoprotein-mediated drug efflux by eliglustat. When the P-gp probe substrate digoxin was given with eliglustat 127 mg twice daily in CYP450 2D6 extensive or intermediate metabolizers and 84 mg twice daily in poor metabolizers, mean digoxin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 1.7- and 1.5-fold, respectively, compared to digoxin administered alone.

MANAGEMENT: Caution is advised when eliglustat is used concurrently with drugs that are known P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever eliglustat is added to or withdrawn from therapy.

Eliglustat

Generic Name: eliglustat

Brand name: Cerdelga

Synonyms: n.a.

What is Eliglustat?

Vitrakvi (Larotrectinib Capsules)

Generic Name: larotrectinib

Brand name: Vitrakvi

Synonyms: Vitrakvi

What is Vitrakvi (Larotrectinib Capsules)?