Eliglustat Tartrate and Janumet XR

• Generic Name: eliglustat
• Dosage Forms: n.a.
• Other Brand Names: Cerdelga

Long-term treatment of nonneuronopathic (type 1) Gaucher disease in patients who are extensive, intermediate, or poor metabolizers of CYP2D6.

Patient selection and dosing based on CYP2D6 metabolizer status; determine patient's CYP2D6 genotype with an FDA-cleared test prior to initiating therapy.

Ultrarapid CYP2D6 metabolizers may not achieve adequate plasma concentrations to achieve a therapeutic effect. A specific dosage cannot be recommended for patients whose CYP2D6 genotype cannot be determined (indeterminate metabolizers).

Designated an orphan drug by FDA for treatment of type 1 Gaucher disease.

• Generic Name: metformin / sitagliptin
• Dosage Forms: tablet, film coated, extended release
• Other Brand Names: Janumet, Janumet XR

Janumet XR are oral diabetes medicines that help control blood sugar levels.

Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Sitagliptin works by regulating the levels of insulin your body produces after eating.

Janumet XR is a combination medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Janumet XR is not for treating type 1 diabetes.

Janumet XR may also be used for purposes not listed in this medication guide.