Eliquis and Kaletra Oral Solution

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ritonavir may significantly increase the blood levels of apixaban. This can increase the risk of serious or life-threatening bleeding complications. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 3A4 that can also inhibit P-glycoprotein (P-gp) may significantly increase the plasma concentrations of apixaban, which is a substrate of both the isoenzyme and efflux transporter. The risk of bleeding associated with apixaban may be increased. When apixaban was coadministered with the dual P-gp and potent CYP450 3A4 inhibitor, ketoconazole (400 mg once daily), mean apixaban peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 1.6- and 2-fold, respectively. The systemic exposure may be increased even more in patients with significant renal impairment.

MANAGEMENT: The use of apixaban should either be avoided or the dosage reduced during concomitant systemic treatment with dual P--gp and potent CYP450 3A4 inhibitors. For patients receiving apixaban 5 mg or 10 mg twice daily, the prescribing information recommends reducing the dosage by 50%. In patients already taking apixaban at a dosage of 2.5 mg twice daily (e,g., patients meeting at least 2 of the following criteria: age >=80 years; body weight =1.5 mg/dL), coadministration with dual P--gp and potent CYP450 3A4 inhibitors should be avoided.

Eliquis

Generic Name: apixaban

Brand name: Eliquis, Eliquis Starter Pack for Treatment of DVT and PE

Synonyms: n.a.

What is Eliquis?

Kaletra Oral Solution

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: Kaletra

What is Kaletra Oral Solution?