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Eliquis Starter Pack and Equetro

Determining the interaction of Eliquis Starter Pack and Equetro and the possibility of their joint administration.

Check result:
Eliquis Starter Pack <> Equetro
Relevance: 05.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

CarBAMazepine can significantly reduce the blood levels of apixaban, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with potent inducers of both CYP450 3A4 and P-glycoprotein (P-gp) may significantly decrease the plasma concentration of apixaban, which is a substrate of the isoenzyme as well as the efflux transporter. When apixaban was coadministered with the potent CYP450 3A4 and P-gp inducer rifampin (600 mg once a day), mean apixaban peak plasma concentration (Cmax) decreased by 42% and systemic exposure (AUC) decreased by 54%. Increased stroke rates, and paradoxically, increased major bleeding have been reported in patients with atrial fibrillation taking concomitant inducers with either apixaban or warfarin.

MANAGEMENT: Concomitant use of apixaban with dual potent inducers of both CYP450 3A4 and P-gp should generally be avoided, since efficacy of apixaban may be compromised.

References
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  • "Product Information. Eliquis (apixaban)." Bristol-Myers Squibb Canada Inc, Montreal, IN.
Eliquis Starter Pack

Generic Name: apixaban

Brand name: Eliquis, Eliquis Starter Pack for Treatment of DVT and PE

Synonyms: Apixaban

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction