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Eltrombopag and Victrelis

Determining the interaction of Eltrombopag and Victrelis and the possibility of their joint administration.

Check result:

Eltrombopag <> Victrelis

Relevance: 24.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with eltrombopag may alter the pharmacokinetics of boceprevir. In 28 healthy volunteers administered a single 200 mg dose of eltrombopag during repeated dosing of boceprevir 800 mg three times daily, boceprevir systemic exposure (AUC) decreased by just 4% but trough plasma level (Cmin) decreased by 32%. The clinical significance is unknown, although the potential for more substantial changes during multiple dosing of eltrombopag cannot be ruled out. Boceprevir did not have an effect on the plasma concentrations of eltrombopag.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Eltrombopag

Generic Name: eltrombopag

Brand name: Promacta

Synonyms: n.a.

What is Eltrombopag?

Victrelis

Generic Name: boceprevir

Brand name: Victrelis

Synonyms: n.a.

What is Victrelis?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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