Elvitegravir, cobicistat, emtricitabine, and tenofovir and Trimipramine Capsules
Determining the interaction of Elvitegravir, cobicistat, emtricitabine, and tenofovir and Trimipramine Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Cobicistat may increase the blood levels and effects of trimipramine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with cobicistat may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 or 2D6 isoenzymes and/or P-glycoprotein (P-gp) efflux transporter.
MANAGEMENT: Caution is advised if cobicistat is used concomitantly with medications that undergo metabolism primarily by CYP450 3A4 and/or 2D6 or are substrates of P-glycoprotein, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever cobicistat is added to or withdrawn from therapy.
- "Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov)." Gilead Sciences, Foster City, CA.
Generic Name: cobicistat / elvitegravir / emtricitabine / tenofovir
Brand name: Genvoya, Stribild
Synonyms: Cobicistat, elvitegravir, emtricitabine, and tenofovir, Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate
Generic Name: trimipramine
Brand name: Surmontil
Synonyms: Trimipramine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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