Emend and Propulsid

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Cisapride is no longer on the market in the US. Do not take cisapride with any other medication.

CONTRAINDICATED: Coadministration with aprepitant or its prodrug, fosaprepitant, may increase the plasma concentrations of cisapride. The mechanism is inhibition of CYP450 3A4-mediated metabolism by aprepitant. High plasma levels of cisapride have been associated with prolongation of the QT interval, which has led to cases of ventricular arrhythmias such as ventricular tachycardia and torsade de pointes as well as cardiac arrest and sudden death.

MANAGEMENT: Given the potential for serious and life-threatening adverse cardiac events associated with increased plasma levels of cisapride, concomitant use of aprepitant or fosaprepitant is considered contraindicated.

Emend

Generic Name: aprepitant

Brand name: Emend, Cinvanti, Emend 3-Day, Emend 2-Day

Synonyms: n.a.

What is Emend?

Propulsid

Generic Name: cisapride

Brand name: Propulsid

Synonyms: Propulsid (Suspension)

What is Propulsid?