Emend for Injection and Escitalopram Tablets
Determining the interaction of Emend for Injection and Escitalopram Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 3A4 is not expected to significantly affect the pharmacokinetics of citalopram or escitalopram, both of which are partially metabolized by the isoenzyme. Administration of racemic citalopram (40 mg) in combination with the potent CYP450 3A4 inhibitor ketoconazole (200 mg) decreased the ketoconazole peak plasma concentration (Cmax) by 21% and systemic exposure (AUC) by 10%, but did not significantly affect the pharmacokinetics of citalopram. Likewise, coadministration of a single 20 mg dose of escitalopram with a single 600 mg dose of ritonavir, another potent CYP450 3A4 inhibitor, did not affect the pharmacokinetics of either drug. Because citalopram and escitalopram are both metabolized by multiple isoenzymes (CYP450 2C19, 3A4, and 2D6), inhibition of a single isoenzyme may not appreciably decrease their clearance.
- "Product Information. Lexapro (escitalopram)." Forest Pharmaceuticals, St. Louis, MO.
- "Product Information. Celexa (citalopram)." Forest Pharmaceuticals, St. Louis, MO.
Generic Name: fosaprepitant
Brand name: Emend for Injection
Synonyms: n.a.
Generic Name: escitalopram
Brand name: Lexapro
Synonyms: Escitalopram
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Emend for Injection-Esclim Transdermal
- Emend for Injection-Eserine
- Emend for Injection-Esgic
- Emend for Injection-Esgic Oral
- Emend for Injection-Esgic Tablets
- Emend for Injection-Esgic-Plus Capsule
- Escitalopram Tablets-Emend Intravenous
- Escitalopram Tablets-Emflaza
- Escitalopram Tablets-Emflaza (Deflazacort Oral Suspension)
- Escitalopram Tablets-Emflaza (Deflazacort Tablets)
- Escitalopram Tablets-Emicizumab
- Escitalopram Tablets-Emicizumab-kxwh