Emend (Fosaprepitant) and Paxil (Paroxetine Tablets)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration of paroxetine and aprepitant may result in decreased plasma concentrations of both drugs. The mechanism of interaction has not been established. According to the labeling for aprepitant, coadministration of paroxetine (20 mg once a day) and aprepitant (once daily as a tablet formulation comparable to 85 mg or 170 mg of the capsule formulation) resulted in an approximately 20% decrease in the peak plasma concentration (Cmax) and a 25% decrease in the area under the concentration-time curve (AUC) of both drugs. The clinical significance of these changes is unknown. Pharmacologic response should be monitored more closely whenever one or the other drug is added to or withdrawn from therapy, and the dosage(s) adjusted as necessary.

Emend (Fosaprepitant)

Generic Name: fosaprepitant

Brand name: Emend for Injection

Synonyms: Fosaprepitant

What is Emend (Fosaprepitant)?

Paxil (Paroxetine Tablets)

Generic Name: paroxetine

Brand name: Paxil, Brisdelle, Paxil CR, Pexeva

Synonyms: Paxil

What is Paxil (Paroxetine Tablets)?