Emend (Fosaprepitant) and Seldane
Determining the interaction of Emend (Fosaprepitant) and Seldane and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Terfenadine is no longer on the market in the US. Do not take terfenadine with any other medication.
Professional:CONTRAINDICATED: Coadministration with aprepitant or its prodrug, fosaprepitant, may increase the plasma concentrations of astemizole and terfenadine. The mechanism is inhibition of CYP450 3A4-mediated metabolism by aprepitant. High plasma levels of astemizole and terfenadine (e.g., due to overdose or interaction with other potent 3A4 inhibitors) have been associated with prolongation of the QT interval, which has led to cases of ventricular arrhythmias such as ventricular tachycardia and torsade de pointes as well as cardiac arrest and sudden death.
MANAGEMENT: Given the potential for serious and life-threatening adverse cardiac events associated with increased plasma levels of astemizole and terfenadine, concomitant use of aprepitant or fosaprepitant is considered contraindicated. Loratadine, cetirizine, or fexofenadine may be safer alternatives.
- "Product Information. Emend (aprepitant)." Merck & Company Inc, West Point, PA.
- "Product Information. Emend for Injection (fosaprepitant)." Merck & Company Inc, West Point, PA.
Generic Name: fosaprepitant
Brand name: Emend for Injection
Synonyms: Fosaprepitant
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Emend (Fosaprepitant)-Select-OB
- Emend (Fosaprepitant)-Select-OB (Prenatal Vitamin Chewable Tablet)
- Emend (Fosaprepitant)-Select-OB (Vitamins (Multiple/Prenatal))
- Emend (Fosaprepitant)-Select-OB+DHA
- Emend (Fosaprepitant)-Selegiline
- Emend (Fosaprepitant)-Selegiline Capsules and Tablets
- Seldane-Emend for Injection
- Seldane-Emend Intravenous
- Seldane-Emflaza
- Seldane-Emflaza (Deflazacort Oral Suspension)
- Seldane-Emflaza (Deflazacort Tablets)
- Seldane-Emicizumab