Emflaza (Deflazacort Tablets) and Lorbrena

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Lorlatinib may significantly reduce the blood levels of deflazacort, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active metabolite of deflazacort that is formed by esterases after oral administration and further metabolized by CYP450 3A4 to several inactive metabolites. According to the product labeling, when deflazacort was administered following multiple doses of rifampin, a strong CYP450 3A4 inducer, mean total exposure to 21-desdeflazacort decreased by approximately 95% compared to administration of deflazacort alone.

MANAGEMENT: Concomitant use of deflazacort with potent or moderate CYP450 3A4 inducers should generally be avoided.

Emflaza (Deflazacort Tablets)

Generic Name: deflazacort

Brand name: Emflaza

Synonyms: Emflaza

What is Emflaza (Deflazacort Tablets)?

Lorbrena

Generic Name: lorlatinib

Brand name: Lorbrena

Synonyms: n.a.

What is Lorbrena?