Emicizumab and Entresto

• Generic Name: emicizumab
• Dosage Forms: n.a.
• Other Brand Names: Hemlibra, Hemlibra 105 mg/07 mL, Hemlibra 60 mg/04 mL

Emicizumab functions in place of a natural blood-clotting factor that is missing in people with hemophilia A. Emicizumab works as a "bridge" between other clotting factors to replace missing factor VIII.

Emicizumab is for adults and children with hemophilia A, with or without factor VIII inhibitors. Emicizumab is used to help prevent bleeding episodes or make them occur less often.

Emicizumab will not stop a bleeding episode that has already begun.

Emicizumab may also be used for purposes not listed in this medication guide.

• Generic Name: sacubitril / valsartan
• Dosage Forms: tablet, film coated
• Other Brand Names: Entresto

Entresto contains a combination of sacubitril and valsartan. Sacubitril is a blood pressure medicine. It works by increasing the levels of certain proteins in the body that can dilate (widen) blood vessels. This helps lower blood pressure by reducing sodium levels.

Valsartan is an angiotensin II receptor blocker (sometimes called an ARB). Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Entresto is used in certain people with chronic heart failure. This medicine helps lower the risk of needing to be hospitalized when symptoms get worse, and helps lower the risk of death from heart failure.

Entresto is also used to treat heart failure in children who are at least 1 year old.

Entresto is usually given together with other heart medications.