Empagliflozin and metformin and Procainamide Hydrochloride
Determining the interaction of Empagliflozin and metformin and Procainamide Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using metFORMIN together with procainamide may increase the effects of metFORMIN. You should monitor your blood glucose and contact your doctor if you experience weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting. You may need a dose adjustment and you may need to check your blood sugar more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Procainamide is a cationic drug and theoretically could decrease the excretion of metformin by competing for renal tubular transport. Although this interaction has not been specifically reported for procainamide, cimetidine (also a cationic drug) has been reported to interact with metformin in this manner. Increased metformin levels may increase the risk of lactic acidosis.
MANAGEMENT: If procainamide and metformin must be used together, particularly slow and cautious titration of metformin dosage is recommended. The maximal dose of metformin probably also should be reduced until further information about this interaction is available. Patients should be advised to monitor their blood glucose and to promptly notify their physician if they experience possible signs of lactic acidosis such as malaise, myalgia, respiratory distress, hyperventilation, slow or irregular heartbeat, somnolence, abdominal upset, or other unusual symptoms.
- Somogyi A, Stockley C, Keal J, Rolan P, Bochner F "Reduction of metformin renal tubular secretion by cimetidine in man." Br J Clin Pharmacol 23 (1987): 545-51
- "Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: empagliflozin / metformin
Brand name: Synjardy, Synjardy XR
Synonyms: Empagliflozin and Metformin
Generic Name: procainamide
Brand name: Pronestyl, Procan SR, Pronestyl-SR, Procanbid
Synonyms: Procainamide (injection), Procainamide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Empagliflozin and metformin-Procainamide injection
- Empagliflozin and metformin-Procainamide Intravenous
- Empagliflozin and metformin-Procaine penicillin
- Empagliflozin and metformin-ProcalAmine
- Empagliflozin and metformin-Procanbid
- Empagliflozin and metformin-Procarbazine
- Procainamide Hydrochloride-Empagliflozin and Metformin Extended-Release Tablets
- Procainamide Hydrochloride-Empagliflozin and Metformin Tablets
- Procainamide Hydrochloride-Empliciti
- Procainamide Hydrochloride-Emsam
- Procainamide Hydrochloride-Emsam Transdermal
- Procainamide Hydrochloride-Emtricitabine