Empagliflozin and Metformin Tablets and Phenobarbital
Determining the interaction of Empagliflozin and Metformin Tablets and Phenobarbital and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration of empagliflozin with inducers of uridine diphosphate glucuronosyl transferase (UGT) enzymes may decrease the plasma concentrations and efficacy of empagliflozin, which is primarily metabolized in vitro by UGT1A3, 1A8, 1A9, and 2B7. The effect of UGT induction on empagliflozin has not been studied. MANAGEMENT: Coadministration of empagliflozin with UGT inducers should be avoided if possible. If concomitant use is required, dosage adjustments as well as increased clinical and laboratory monitoring should be considered whenever a UGT inducer is added to or withdrawn from empagliflozin therapy. References "Product Information. Glyxambi (empagliflozin-linagliptin)." Boehringer Ingelheim, Ridgefield, CT. "Product Information. Jardiance (empagliflozin)." Boehringer Ingelheim, Ridgefield, CT. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Cerner Multum, Inc. "Australian Product Information." O 0 View all 4 references
Professional:GENERALLY AVOID: Coadministration of empagliflozin with inducers of uridine diphosphate glucuronosyl transferase (UGT) enzymes may decrease the plasma concentrations and efficacy of empagliflozin, which is primarily metabolized in vitro by UGT1A3, 1A8, 1A9, and 2B7. The effect of UGT induction on empagliflozin has not been studied.
MANAGEMENT: Coadministration of empagliflozin with UGT inducers should be avoided if possible. If concomitant use is required, dosage adjustments as well as increased clinical and laboratory monitoring should be considered whenever a UGT inducer is added to or withdrawn from empagliflozin therapy.
- "Product Information. Glyxambi (empagliflozin-linagliptin)." Boehringer Ingelheim, Ridgefield, CT.
- "Product Information. Jardiance (empagliflozin)." Boehringer Ingelheim, Ridgefield, CT.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: empagliflozin / metformin
Brand name: Synjardy, Synjardy XR
Synonyms: Empagliflozin and metformin, Empagliflozin and Metformin
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: PHENobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Empagliflozin and Metformin Tablets-Phenobarbital Elixir
- Empagliflozin and Metformin Tablets-Phenobarbital Injection
- Empagliflozin and Metformin Tablets-Phenobarbital Oral Solution
- Empagliflozin and Metformin Tablets-Phenobarbital Sodium
- Empagliflozin and Metformin Tablets-Phenobarbital Sodium Injection
- Empagliflozin and Metformin Tablets-Phenobarbital Tablets
- Phenobarbital-Empliciti
- Phenobarbital-Emsam
- Phenobarbital-Emsam Transdermal
- Phenobarbital-Emtricitabine
- Phenobarbital-Emtricitabine and tenofovir
- Phenobarbital-Emtricitabine and Tenofovir Alafenamide