Emtricitabine and tenofovir and Ethacrynate Sodium

• Generic Name: emtricitabine / tenofovir
• Dosage Forms: n.a.
• Other Brand Names: AccessPak for HIV PEP Basic, Descovy, Truvada

Emtricitabine and tenofovir are antiviral medicines that prevent human immunodeficiency virus (HIV) from multiplying in your body.

Emtricitabine and tenofovir is a combination medicine used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). emtricitabine and tenofovir is not a cure for HIV or AIDS, but it can be used to treat HIV in adults and children who are at least 12 years old and weigh at least 17 kilograms (37 pounds).

Emtricitabine and tenofovir is also used in children who weigh between 55 and 77 pounds (25 to 35 kilograms) and who take certain other HIV medications.

Truvada PrEP is used together with safer-sex practices to reduce the risk of becoming infected with HIV. You must be HIV-negative and an adult to use Truvada PrEP for this purpose.

Emtricitabine and tenofovir may also be used for purposes not listed in this medication guide.

• Generic Name: ethacrynic acid
• Dosage Forms: n.a.
• Other Brand Names: Edecrin, Edecrin Sodium, Sodium Edecrin

Management of edema associated with heart failure, hepatic cirrhosis, and renal disease (e.g., nephrotic syndrome).

Considered a diuretic of choice for most patients with heart failure.

Most experts state that all patients with symptomatic heart failure who have evidence for, or a history of, fluid retention generally should receive diuretic therapy in conjunction with moderate sodium restriction, an agent to inhibit the renin-angiotensin-aldosterone (RAA) system (e.g., ACE inhibitor, angiotensin II receptor antagonist, angiotensin receptor-neprilysin inhibitor [ARNI]), a β-adrenergic blocking agent (β-blocker), and in selected patients, an aldosterone antagonist.

Short-term management of ascites associated with malignancy, idiopathic edema, or lymphedema.

Short-term management of hospitalized pediatric patients, other than infants, with congenital heart disease or nephrotic syndrome. (See Pediatric Use under Cautions.)

IV ethacrynate sodium is used when rapid onset of diuresis is needed (e.g., acute pulmonary edema).

Has been used in the management of hypertension. However, not a recommended agent in current hypertension management guidelines.

May still be considered when diuretic therapy is indicated in patients hypersensitive to sulfonamides (e.g., other loop diuretics, thiazides) because ethacrynic acid is not a sulfonamide.

IV ethacrynate sodium has been used as an adjunct to hypotensive agents in the management of hypertensive crisis, especially when accompanied by pulmonary edema.

IV ethacrynate sodium has been used in the management of hypercalcemia, alone or with sodium chloride 0.9% injection.

Has been used with mannitol in the management of ethylene glycol poisoning.

Management of bromide intoxication.

Treatment of nephrogenic diabetes insipidus that is refractory to vasopressin or chlorpropamide.