Emtricitabine and Tenofovir Disoproxil Fumarate and Intelence
Determining the interaction of Emtricitabine and Tenofovir Disoproxil Fumarate and Intelence and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with tenofovir may reduce the plasma concentrations of etravirine. The mechanism of interaction has not been described. In 23 study subjects administered etravirine with tenofovir disoproxil fumarate 300 mg once a day, etravirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) decreased by nearly 20% each. These changes were statistically, but not clinically, significant. Etravirine had no effect on the pharmacokinetics of tenofovir. Etravirine and tenofovir disoproxil fumarate may be coadministered without any dosage adjustments.
- "Product Information. Intelence (etravirine)." Ortho Biotech Inc, Bridgewater, NJ.
Generic Name: emtricitabine / tenofovir
Brand name: AccessPak for HIV PEP Basic, Descovy, Truvada
Synonyms: Emtricitabine and tenofovir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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