Emtricitabine, Rilpivirine, and Tenofovir Disoproxil Fumarate and Neut

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

By reducing the acidity level in the stomach, sodium bicarbonate can decrease the absorption and blood levels of rilpivirine and make the medication less effective against HIV. To minimize the risk of interaction, sodium bicarbonate should be taken at least 2 hours before or 4 hours after you take rilpivirine. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Coadministration with antacids may decrease the oral bioavailability of rilpivirine. The proposed mechanism involves a pH-dependent reduction in dissolution and absorption of rilpivirine, which is poorly soluble over a wide pH range. The interaction has not been studied specifically with antacids, but has been reported for H2-receptor antagonists and proton pump inhibitors.

MANAGEMENT: To minimize the risk of reduced viral susceptibility and resistance development associated with subtherapeutic levels of rilpivirine, antacids or other medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution) should be administered at least 2 hours before or 4 hours after the rilpivirine dose.

Emtricitabine, Rilpivirine, and Tenofovir Disoproxil Fumarate

Generic Name: emtricitabine / rilpivirine / tenofovir

Brand name: Complera, Odefsey

Synonyms: Emtricitabine, rilpivirine, and tenofovir

What is Emtricitabine, Rilpivirine, and Tenofovir Disoproxil Fumarate?

Neut

Generic Name: sodium bicarbonate

Brand name: Neut

Synonyms: Neut Injection

What is Neut?