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Emtricitabine, Rilpivirine, and Tenofovir Disoproxil Fumarate and PCE Dispertab

Determining the interaction of Emtricitabine, Rilpivirine, and Tenofovir Disoproxil Fumarate and PCE Dispertab and the possibility of their joint administration.

Check result:
Emtricitabine, Rilpivirine, and Tenofovir Disoproxil Fumarate <> PCE Dispertab
Relevance: 05.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using rilpivirine together with erythromycin. Combining these medications may increase the blood levels and effects of rilpivirine. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with macrolide antibiotics that are inhibitors of CYP450 3A4 may increase the blood concentrations of rilpivirine, which is primarily metabolized by the isoenzyme.

MANAGEMENT: Caution is advised if rilpivirine is used with macrolide antibiotics that are inhibitors of CYP450 3A4. Alternative antibiotics that do not interfere with rilpivirine metabolism, such as azithromycin, should be considered whenever possible.

References
  • "Product Information. Edurant (rilpivirine)." Tibotec Pharmaceuticals, Titusville, NJ.
Emtricitabine, Rilpivirine, and Tenofovir Disoproxil Fumarate

Generic Name: emtricitabine / rilpivirine / tenofovir

Brand name: Complera, Odefsey

Synonyms: Emtricitabine, rilpivirine, and tenofovir

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.