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Emtricitabine Solution and Triumeq

Determining the interaction of Emtricitabine Solution and Triumeq and the possibility of their joint administration.

Check result:

Emtricitabine Solution <> Triumeq

Relevance: 20.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using lamiVUDine together with emtricitabine is generally not recommended. Combining these medications is not expected to substantially enhance activity against HIV. In fact, there is reason to believe that overall effectiveness may diminish due to possible antagonistic effects pertaining to how these medications are activated in the body. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Concomitant use of the cytidine analog nucleoside reverse transcriptase inhibitors (NRTI) lamivudine and emtricitabine may inhibit the intracellular phosphorylation of one another to their respective active derivative in vivo. This could result in diminished antiretroviral effects of these drugs. However, clinical experience on the coadministration of cytidine analogs is lacking. This interaction may also occur with zalcitabine. In addition, the therapeutic efficacy of these drugs in combination appears limited, since lamivudine and emtricitabine have similar resistance profiles via mutation of the same viral reverse transcriptase gene (M184V).

MANAGEMENT: The use of the cytidine analog NRTIs lamivudine, emtricitabine, or zalcitabine in any combination in an antiretroviral treatment regimen that consists of two NRTIs is not recommended. Local antiretroviral treatment experts should be consulted for current practice.

References

Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Veal GJ, Hoggard PG, Barry MG, Khoo S, Back DJ "Interaction between lamivudine (3TC) and other nucleoside analogues for intracellular phosphorylation." AIDS 10 (1996): 546-8
"Product Information. Epivir (lamivudine)." Glaxo Wellcome, Research Triangle Park, NC.
Department of Health and Human Services "Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Available from: URL: https://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultAndAdolescentGL.pdf." ([2015, April 8]):

Emtricitabine Solution

Generic Name: emtricitabine

Brand name: Emtriva

Synonyms: Emtricitabine

What is Emtricitabine Solution?

Triumeq

Generic Name: abacavir / dolutegravir / lamivudine

Brand name: Triumeq

Synonyms: n.a.

What is Triumeq?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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