Enablex and Phenytoin Sodium, Prompt injection
Determining the interaction of Enablex and Phenytoin Sodium, Prompt injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Phenytoin may reduce the blood levels and effects of darifenacin. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Theoretically, coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of darifenacin, which has been shown to be a substrate of the isoenzyme.
MANAGEMENT: Pharmacologic response to darifenacin should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the darifenacin dosage adjusted if necessary.
- "Product Information. Enablex (darifenacin)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: phenytoin
Brand name: Dilantin, Phenytoin Sodium, Prompt, Phenytek, Dilantin Infatabs
Synonyms: Phenytoin Sodium, Prompt (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Enablex-Phenytoin Suspension
- Enablex-Philith
- Enablex-Phillips Milk of Magnesia
- Enablex-Phisohex
- Enablex-Phl-Fluoxetine
- Enablex-Phlemex
- Phenytoin Sodium, Prompt injection-Enalapril
- Phenytoin Sodium, Prompt injection-Enalapril and Hydrochlorothiazide
- Phenytoin Sodium, Prompt injection-Enalapril Oral Solution
- Phenytoin Sodium, Prompt injection-Enalapril Tablets
- Phenytoin Sodium, Prompt injection-Enalapril Tablets Soluble
- Phenytoin Sodium, Prompt injection-Enalaprilat