Enalapril Oral Solution and Epoetin alfa-epbx Injection
Determining the interaction of Enalapril Oral Solution and Epoetin alfa-epbx Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Angiotensin-converting enzyme (ACE) inhibitors may interfere with the effects of both endogenous and exogenous erythropoietin, although data are conflicting with respect to the latter. A retrospective investigation of 43 dialysis patients treated with human recombinant erythropoietin for an average of ten months found that the group also receiving captopril had lower hemoglobin and hematocrit levels than the control group when given the same dosage of erythropoietin, and the difference was statistically significant. However, another retrospective investigation found no significant differences in the mean hematocrit level and erythropoietin dosage in 14 stable hemodialysis patients for up to 16 weeks before and 16 weeks after initiation of ACE inhibitor therapy. Previous studies have suggested that ACE inhibitors may interfere with hematopoiesis by decreasing the synthesis of endogenous erythropoietin or decreasing bone marrow production of red blood cells, but an actual pharmacokinetic or pharmacodynamic interaction with erythropoietin has not been reported. Until further data are available, it may be appropriate to monitor patients for potentially diminished hematopoietic response to recombinant erythropoietin therapy following the addition of an ACE inhibitor. It is not known if other erythropoiesis-stimulating agents are similarly affected.
- Walter J "Does captopril decrease the effect of human recombinant erythropoietin in hemodialysis patients?" Nephrol Dial Transplant 8 (1993): 1428-31
- Conlon PJ, Albers F, Butterly D, Schwab SJ "ACE inhibitors do not affect erythropoietin efficacy in haemodialysis patients." Nephrol Dial Transplant 9 (1994): 1358
Generic Name: enalapril
Brand name: Epaned, Vasotec
Synonyms: Enalapril
Generic Name: epoetin alfa
Brand name: Epogen, Procrit, Retacrit
Synonyms: Epoetin alfa, Epoetin Alfa
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Enalapril Oral Solution-Epoetin beta and methoxy polyethylene glycol
- Enalapril Oral Solution-Epogen
- Enalapril Oral Solution-Epoprostenol
- Enalapril Oral Solution-Epoprostenol Intravenous
- Enalapril Oral Solution-Epoprostenol Sodium
- Enalapril Oral Solution-Eposin
- Epoetin alfa-epbx Injection-Enalapril Tablets
- Epoetin alfa-epbx Injection-Enalapril Tablets Soluble
- Epoetin alfa-epbx Injection-Enalaprilat
- Epoetin alfa-epbx Injection-Enalaprilat Intravenous
- Epoetin alfa-epbx Injection-Enalaprilat/Enalapril Maleate
- Epoetin alfa-epbx Injection-Enasidenib