Enalapril Oral Solution and Nitroglycerin Slocaps
Determining the interaction of Enalapril Oral Solution and Nitroglycerin Slocaps and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using enalapril and nitroglycerin together may lower your blood pressure and slow your heart rate. This can cause a throbbing headache, difficult or slow breathing, dizziness, fainting, and an irregular heartbeat. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Angiotensin converting enzyme (ACE) inhibitors may enhance the vasodilatory and hypotensive effects of nitroglycerin. Data have also shown that captopril can prevent nitrate tolerance. ACE inhibitors can decrease systemic vascular resistance and cardiac work, further enhancing the effectiveness of nitroglycerin.
MANAGEMENT: In general, this combination is used to clinical advantage; however, some manufacturers recommend that nitrates and other vasodilators should be discontinued before starting ACE inhibitors or resumed at a reduced dose. Blood pressure monitoring is advisable.
- Katz RJ, Levy WS, Buff L, Wasserman AG "Prevention of nitrate tolerance with angiotension converting enzyme inhibitors." Circulation 83 (1991): 1271-7
Generic Name: enalapril
Brand name: Epaned, Vasotec
Synonyms: Enalapril
Generic Name: nitroglycerin
Brand name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv
Synonyms: Nitroglycerin (oral/sublingual), Nitroglycerin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Enalapril Oral Solution-Nitroglycerin Spray
- Enalapril Oral Solution-Nitroglycerin Sublingual Powder
- Enalapril Oral Solution-Nitroglycerin Sublingual Tablet
- Enalapril Oral Solution-Nitroglycerin Sublingual Tablets
- Enalapril Oral Solution-Nitroglycerin topical
- Enalapril Oral Solution-Nitroglycerin transdermal
- Nitroglycerin Slocaps-Enalapril Tablets
- Nitroglycerin Slocaps-Enalapril Tablets Soluble
- Nitroglycerin Slocaps-Enalaprilat
- Nitroglycerin Slocaps-Enalaprilat Intravenous
- Nitroglycerin Slocaps-Enalaprilat/Enalapril Maleate
- Nitroglycerin Slocaps-Enasidenib