Enalaprilat Intravenous and Isosorbide dinitrate Oral, Sublingual
Determining the interaction of Enalaprilat Intravenous and Isosorbide dinitrate Oral, Sublingual and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using enalapril and isosorbide dinitrate together may lower your blood pressure and slow your heart rate. This can cause a throbbing headache, difficult or slow breathing, dizziness, fainting, and an irregular heartbeat. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Angiotensin converting enzyme (ACE) inhibitors may enhance the vasodilatory and hypotensive effects of nitroglycerin. Data have also shown that captopril can prevent nitrate tolerance. ACE inhibitors can decrease systemic vascular resistance and cardiac work, further enhancing the effectiveness of nitroglycerin.
MANAGEMENT: In general, this combination is used to clinical advantage; however, some manufacturers recommend that nitrates and other vasodilators should be discontinued before starting ACE inhibitors or resumed at a reduced dose. Blood pressure monitoring is advisable.
- Katz RJ, Levy WS, Buff L, Wasserman AG "Prevention of nitrate tolerance with angiotension converting enzyme inhibitors." Circulation 83 (1991): 1271-7
Generic Name: enalaprilat
Brand name:
Synonyms: Enalaprilat
Generic Name: isosorbide dinitrate
Brand name: Dilatrate-SR, Isochron, Isordil, Sorbitrate, Isordil Titradose, ISDN, Isordil Tembids
Synonyms: Isosorbide dinitrate, Isosorbide Dinitrate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Enalaprilat Intravenous-Isosorbide Dinitrate Tablets
- Enalaprilat Intravenous-Isosorbide mononitrate
- Enalaprilat Intravenous-Isosorbide Mononitrate Extended Release
- Enalaprilat Intravenous-Isosorbide Mononitrate Extended-Release Tablets
- Enalaprilat Intravenous-Isosorbide Mononitrate Tablets
- Enalaprilat Intravenous-Isotretinoin
- Isosorbide dinitrate Oral, Sublingual-Enalaprilat/Enalapril Maleate
- Isosorbide dinitrate Oral, Sublingual-Enasidenib
- Isosorbide dinitrate Oral, Sublingual-Enasidenib Mesylate
- Isosorbide dinitrate Oral, Sublingual-EnBrace HR
- Isosorbide dinitrate Oral, Sublingual-Enbrel
- Isosorbide dinitrate Oral, Sublingual-Enbrel (Etanercept Prefilled Syringes)