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Endocet and Probenecid

Determining the interaction of Endocet and Probenecid and the possibility of their joint administration.

Check result:

Endocet <> Probenecid

Relevance: 25.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Probenecid may slightly increase the therapeutic effects of acetaminophen. At usual doses, however, no intervention appears to be necessary.

References

Kamali F, Fry JR, Bell GD "Salivary excretion of paracetamol in man." J Pharm Pharmacol 39 (1987): 150-2
Abernethy DR, Greenblatt DJ, Ameer B, Shader RI "Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation." J Pharmacol Exp Ther 234 (1985): 345-9

Endocet

Generic Name: acetaminophen / oxycodone

Brand name: Endocet, Percocet, Primalev, Roxicet, Xartemis XR, Endocet 10/325, Endocet 25/325, Endocet 5/325, Endocet 75/325, Nalocet, Percocet 10/325, Percocet 25/325, Percocet 5/325, Percocet 75/325, Primlev, Tylox, Roxilox, Percocet 10/650, Percocet 75/500, Perloxx, Magnacet, Narvox, Xolox

Synonyms: n.a.

What is Endocet?

Probenecid

Generic Name: probenecid

Brand name: Benemid

Synonyms: n.a.

What is Probenecid?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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