Enfuvirtide and Lopinavir and Ritonavir Oral Solution
Determining the interaction of Enfuvirtide and Lopinavir and Ritonavir Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with ritonavir and/or saquinavir may slightly increase the plasma concentrations of enfuvirtide. The mechanism of interaction is unknown. According to the manufacturer, ritonavir (200 mg every 12 hours for 4 days) increased the steady-state peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and trough concentration (Cmin) of enfuvirtide (90 mg twice a day) by 24%, 22% and 14%, respectively, in 12 HIV-positive subjects. Saquinavir-ritonavir (1000 mg-100 mg every 12 hours for 4 days) increased enfuvirtide AUC by 14% and Cmin by 26% but did not affect Cmax. These alterations are not considered to be clinically significant.
- "Product Information. Fuzeon (enfuvirtide)." Roche Laboratories, Nutley, NJ.
Generic Name: lopinavir / ritonavir
Brand name: Kaletra
Synonyms: Lopinavir and ritonavir, Lopinavir and Ritonavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Enfuvirtide-Lopinavir and Ritonavir Solution
- Enfuvirtide-Lopinavir and Ritonavir Tablets
- Enfuvirtide-Lopreeza
- Enfuvirtide-Lopressor
- Enfuvirtide-Lopressor (Metoprolol Injection)
- Enfuvirtide-Lopressor (Metoprolol Tablets)
- Lopinavir and Ritonavir Oral Solution-Enfuvirtide Subcutaneous
- Lopinavir and Ritonavir Oral Solution-Engerix-B
- Lopinavir and Ritonavir Oral Solution-Engerix-B Pediatric
- Lopinavir and Ritonavir Oral Solution-Enjuvia
- Lopinavir and Ritonavir Oral Solution-Enjuvia Oral
- Lopinavir and Ritonavir Oral Solution-Enlon