Entacapone and Flintstones Toddler

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Entacapone can bind to iron in the gastrointestinal tract. This may inactivate the iron and also interfere with the absorption of entacapone into the bloodstream. The effectiveness of both medications may be reduced. To avoid or minimize the interaction, the dosing times of entacapone and multivitamin with iron (or any other iron-containing medication) should be separated by at least 2 to 3 hours. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: The oral bioavailability of entacapone and iron salts may be decreased during concurrent administration. The proposed mechanism is chelation of iron by entacapone, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract. Entacapone has been shown to be a chelator of iron. The impact of entacapone on the body's iron stores is unknown, but in clinical trials, a tendency towards decreasing serum iron concentrations was reported. In one controlled study, serum ferritin levels (a marker of iron deficiency and subclinical anemia) were not altered with entacapone compared to placebo, and there was no difference in frequency of anemia or decreased hemoglobin levels. However, slight decreases in hemoglobin, erythrocyte count, and hematocrit have been reported during entacapone treatment. After 6 months of entacapone therapy, a clinically significant decrease in hemoglobin has been observed in 1.5% of patients.

MANAGEMENT: Patients receiving entacapone concomitantly with iron-containing products should be advised to separate the times of administration by 2 to 3 hours.

Entacapone

Generic Name: entacapone

Brand name: Comtan

Synonyms: n.a.

What is Entacapone?

Flintstones Toddler

Generic Name: multivitamin with iron

Brand name: Fero-Folic 500, Theragran Hematinic, Ultra Enerforce

Synonyms: Multivitamin with iron, Polysaccharide-Iron Complex, Vitamin B12, and Folic Acid

What is Flintstones Toddler?