Entereg and Esomeprazole Sodium

• Generic Name: alvimopan
• Dosage Forms: capsule
• Other Brand Names: Entereg

Entereg (alvimopan) reduces certain side effects of narcotic medicines that are often used to prevent pain caused by surgery. Narcotic medicine can cause stomach pain, bloating, nausea, vomiting, and constipation. These side effects can delay recovery in patients undergoing gastrointestinal surgery.

Entereg helps prevent these side effects without reducing the pain-relieving effects of the narcotic.

Entereg is used to help restore normal digestive functioning after surgery to remove a portion of your intestine. This medicine is available only under a special program for short-term use (no more than 15 doses). You must be registered in the program and understand the risks and benefits of taking this medicine.

• Generic Name: esomeprazole
• Dosage Forms: n.a.
• Other Brand Names: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV

Short-term treatment of symptomatic GERD (e.g., heartburn) in patients without erosive esophagitis.

Short-term treatment of erosive esophagitis (diagnostically confirmed) in patients with GERD. Short-term treatment of erosive esophagitis due to acid-mediated GERD in infants.

Maintain healing, symptom resolution, and decrease recurrence of erosive esophagitis.

IV as short-term alternative to oral therapy in patients with erosive esophagitis who are unable to take the drug orally; safety and efficacy not established beyond 10 days.

Treatment of Helicobacter pylori infection and duodenal ulcer disease (active duodenal ulcer or history of duodenal ulcer in the past 5 years). Used in conjunction with amoxicillin and clarithromycin (triple therapy).

Reduction in the occurrence of gastric ulcers associated with chronic NSAIA therapy in patients at risk (i.e., ≥60 years of age and/or history of gastric ulcer). Effect on occurrence of duodenal ulcers not established.

Some evidence for use of proton-pump inhibitors (e.g., omeprazole) for gastric acid suppressive therapy as an adjunct in the management of upper GI Crohn’s disease, including esophageal, gastroduodenal, and jejunoileal disease.