Envarsus XR and Imbruvica (Ibrutinib Tablets)
Determining the interaction of Envarsus XR and Imbruvica (Ibrutinib Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ibrutinib may increase the blood levels and effects of tacrolimus. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with ibrutinib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) efflux transporter. In vitro studies indicate that ibrutinib is not a substrate for P-gp, and systemic ibrutinib is unlikely to be an inhibitor of P-gp at clinical doses. However, it may have an effect on P-gp substrates in the gastrointestinal tract due to higher local concentrations after an oral dose.
MANAGEMENT: Caution is advised if ibrutinib is prescribed in combination with orally administered P-gp substrates, particularly those with a narrow therapeutic range. Dosage reduction and/or dosage interval adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever ibrutinib is added to or withdrawn from therapy. Some authorities recommend that narrow therapeutic range P-gp substrates, such as digoxin, should be administered at least 6 hours before or after ibrutinib.
- "Product Information. Imbruvica (ibrutinib)." Pharmacyclics Inc, Sunnyvale, CA.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: tacrolimus
Brand name: Envarsus XR, Astagraf XL, Prograf, Hecoria
Synonyms: n.a.
Generic Name: ibrutinib
Brand name: Imbruvica
Synonyms: Imbruvica
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Envarsus XR-Imdur
- Envarsus XR-Imdur ER
- Envarsus XR-Imfinzi
- Envarsus XR-Imiglucerase
- Envarsus XR-Imiglucerase Intravenous
- Envarsus XR-Imipenem and cilastatin
- Imbruvica (Ibrutinib Tablets)-Enzalutamide
- Imbruvica (Ibrutinib Tablets)-Enzoclear Foam
- Imbruvica (Ibrutinib Tablets)-Eolarix
- Imbruvica (Ibrutinib Tablets)-Eovist
- Imbruvica (Ibrutinib Tablets)-Epaned
- Imbruvica (Ibrutinib Tablets)-Epanova