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Enzalutamide and Sudafed 12 Hour Pressure + Pain

Determining the interaction of Enzalutamide and Sudafed 12 Hour Pressure + Pain and the possibility of their joint administration.

Check result:

Enzalutamide <> Sudafed 12 Hour Pressure + Pain

Relevance: 11.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Enzalutamide may decrease the blood levels and effects of naproxen. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with enzalutamide may decrease the plasma concentrations of drugs that are substrates of CYP450 3A4, 2C9, 2C19, and/or P-glycoprotein (P-gp) efflux transporter. The proposed mechanism involves accelerated clearance via these routes due to enzalutamide-mediated induction. The resulting plasma concentrations will depend on the sensitivity of the affected drugs to these isoenzymes.

MANAGEMENT: Caution is advised when enzalutamide is used concomitantly with drugs that are substrates of CYP450 3A4, 2C9, 2C19, and/or P-gp, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever enzalutamide is added to or withdrawn from therapy.

References

Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Xtandi (enzalutamide)." Astellas Pharma US, Inc, Deerfield, IL.
Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Enzalutamide

Generic Name: enzalutamide

Brand name: Xtandi

Synonyms: n.a.

What is Enzalutamide?

Sudafed 12 Hour Pressure + Pain

Generic Name: naproxen / pseudoephedrine

Brand name: Aleve-D Sinus & Cold, Aleve-D Sinus & Headache, Sudafed 12 Hour Pressure + Pain, Aleve Cold and Sinus, Aleve Sinus & Headache, Sudafed PSE, Aleve-D Cold and Sinus, Sudafed Sinus & Pain 12 Hour, Sinus & Cold-D, Sudafed Sinus 12 Hour Pressure + Pain

Synonyms: n.a.

What is Sudafed 12 Hour Pressure + Pain?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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