Epclusa and Zantac

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Depending on the dose, raNITIdine may interfere with the absorption of velpatasvir and reduce its effectiveness. Talk to your doctor or pharmacist if you have any questions or concerns. You may need a dose adjustment of raNITIdine to safely use both medications. You should take raNITIdine simultaneously with or 12 hours apart from the dose of velpatasvir. Contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration of velpatasvir with H2-receptor antagonists may reduce its gastrointestinal absorption. Velpatasvir exhibits pH-dependent solubility, with increased solubility at lower pH. In 60 healthy volunteers, mean velpatasvir peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 20% and 19%, respectively, when a single 400 mg-100 mg dose of sofosbuvir-velpatasvir was administered simultaneously with a 40 mg dose of famotidine. When the famotidine dose was given 12 hours before the sofosbuvir-velpatasvir dose, mean velpatasvir Cmax decreased by 13% and AUC decreased by 15%. These alterations are not considered clinically significant. However, higher dosages of famotidine or another H2-receptor antagonist may result in a greater magnitude of interaction.

MANAGEMENT: H2-receptor antagonists may be administered simultaneously with or 12 hours apart from sofosbuvir-velpatasvir at a dose that does not exceed the equivalent of famotidine 40 mg twice daily.

Epclusa

Generic Name: sofosbuvir / velpatasvir

Brand name: Epclusa

Synonyms: n.a.

What is Epclusa?

Zantac

Generic Name: ranitidine

Brand name: Zantac

Synonyms: n.a.

What is Zantac?