Ephedrine Sulphate Injection and Polyethylene Glycol-Electrolyte Solution and Bisacodyl
Determining the interaction of Ephedrine Sulphate Injection and Polyethylene Glycol-Electrolyte Solution and Bisacodyl and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using ePHEDrine together with sodium bicarbonate may increase the effects of ePHEDrine. Contact your doctor if you experience tremor, anxiety, insomnia, irritability, or nervousness. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Alkalization of the urine decreases the urinary excretion increases the elimination half-life of ephedrine, pseudoephedrine, and related drugs. According to one report, an increase in pH from 5.1 to 7.1 increased the half-life of pseudoephedrine from 5 to 16 hours. Toxicity from long-term use of pseudoephedrine has been demonstrated in patients with persistently alkaline urine.
MANAGEMENT: Patients should be monitored for toxic effects such as tremor, anxiety, insomnia, irritability, or nervousness. Dosage reductions may be required.
- Kuntzman RG, Tsai I, Brand L, Mark LC "The influence of urinary pH on the plasma half-life of pseudoephedrine in man and dog and a sensitive assay for its determination in human plasma." Clin Pharmacol Ther 12 (1971): 62-7
- Brater DC, Kaojarern S, Benet LZ, et al "Renal excretion of pseudoephedrine." Clin Pharmacol Ther 28 (1980): 690-4
- Wilkinson GR, Beckett AH "Absorption metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output." J Pharmacol Exp Ther 162 (1968): 139-47
Generic Name: ephedrine
Brand name: Akovaz
Synonyms: Ephedrine, EPHEDrine (Systemic)
Generic Name: bisacodyl / polyethylene glycol 3350 / potassium chloride / sodium bicarbonate / sodium chloride
Brand name: Half Lytely and Bisacodyl Lemon Lime, HalfLytely and Bisacodyl, HalfLytely and Bisacodyl with Flavor Packs, GaviLyte-H and Bisacodyl with Flavor Packs
Synonyms: Bisacodyl and polyethylene glycol (PEG) 3350 with electrolytes
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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