Epidiolex and Isavuconazonium Sulfate Injection
Determining the interaction of Epidiolex and Isavuconazonium Sulfate Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Isavuconazonium may increase the blood levels of cannabidiol. This may increase side effects such as drowsiness, diarrhea, decreased appetite, and liver problems. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: Coadministration with moderate or potent inhibitors of CYP450 2C19 and/or CYP450 3A4 may increase the plasma concentrations of cannabidiol, which is primarily metabolized by these isoenzymes in the liver and gut.
MANAGEMENT: Dosage reduction of cannabidiol should be considered when coadministered with moderate or potent inhibitors of CYP450 2C19 and/or CYP450 3A4.
- "Product Information. Epidiolex (cannabidiol)." Greenwich Biosciences Inc, Carlsbad, CA.
Generic Name: cannabidiol
Brand name: Epidiolex
Synonyms: Epidiolex Oral Solution
Generic Name: isavuconazonium
Brand name: Cresemba
Synonyms: Isavuconazonium, Isavuconazonium Sulfate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Epidiolex-Isentress
- Epidiolex-Isentress (Raltegravir Chewable Tablets)
- Epidiolex-Isentress (Raltegravir Powder for Oral Suspension)
- Epidiolex-Isentress (Raltegravir Tablets)
- Epidiolex-Isentress HD
- Epidiolex-Isibloom
- Isavuconazonium Sulfate Injection-Epidiolex Oral Solution
- Isavuconazonium Sulfate Injection-Epiduo
- Isavuconazonium Sulfate Injection-Epiduo Forte
- Isavuconazonium Sulfate Injection-Epifoam
- Isavuconazonium Sulfate Injection-Epiject Iv
- Isavuconazonium Sulfate Injection-Epiklor